Human Genetics and Genomics bridges fundamental molecular research with clinical practice, public health initiatives, and policy development, driving transformative healthcare innovations while navigating ethical complexities. Its interdisciplinary framework fosters collaboration across scientific, medical, and societal domains, advancing both human health and our understanding of biological systems. This special issue highlights groundbreaking contributions across four thematic areas: Ancient Genomics and Population History, Medical and Disease Genetics, Forensic and Technological Innovations, and Population-Specific Genomic Diversity. Collectively, these studies deepen insights into human evolution, disease mechanisms, and global genetic variation. By integrating methodologies such as genome-wide association studies (GWAS), epigenetic profiling, and structural variant analysis, the research lays a foundation for personalized medicine, enhances forensic applications, and illuminates connections between historical migration patterns and modern genetic diversity. Together, they underscore the field’s pivotal role in shaping equitable healthcare strategies and decoding the intricate tapestry of human heredity.

Edited by

Prof. Shuhua Xu - Fudan University, Shanghai, China

Prof. Chuan-Chao Wang - Xiamen University, Xiamen, China

Prof. Xin Jin - BGI-Shenzhen, Guangdong, China

Prof. Hou-Feng Zheng - Westlake University, Zhejiang, China

Prof. Li Jin - Fudan University, Shanghai, China

Pages 449-600 (April 2025)