Genetic basis of canine separation-related behavior: putative enhancer-dependent regulation of <i>SLC32A1</i> and conservation in human psychiatric disorders

Yun Yu; Yaoyue Wu; Huairen Zhao; Zijuan Zhou; Jing Bai; Yuedong Zhang; Fengyun Zhang; Bowen Zhou; Jingyu Wang; Ya-Ping Zhang

doi:10.1016/j.jgg.2026.03.003

Volume 53 Issue 8

Aug. 2026

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Article Navigation > Journal of Genetics and Genomics > 2026 > 53(8): 1563-1566

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Genetic basis of canine separation-related behavior: putative enhancer-dependent regulation of SLC32A1 and conservation in human psychiatric disorders

doi: 10.1016/j.jgg.2026.03.003

1. State Key Laboratory of Genetic Evolution & Animal Models and Yunnan Key Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650201, China;
2. State Key Laboratory of Genetic Evolution & Animal Models and Yunnan Key Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650201, China;
3. Bio-X Center for Interdisciplinary Innovation, Yunnan University, Kunming, Yunnan 650500, China;
4. Laboratory Animal Center, Dalian Medical University, Dalian, Liaoning 116044, China;
5. State Key Laboratory of Genetic Evolution & Animal Models and Yunnan Key Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650201, China;
6. Laboratory Animal Center, Dalian Medical University, Dalian, Liaoning 116044, China;
7. State Key Laboratory of Genetic Evolution & Animal Models and Yunnan Key Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650201, China;
8. Bio-X Center for Interdisciplinary Innovation, Yunnan University, Kunming, Yunnan 650500, China;
9. KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China;
10. Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China

Funds:

This work was supported by the STI2030-Major Projects (2021ZD0203900), the National Natural Science Foundation of China (32302737), National Key R&D Program of China (2019YFA0707101), Spring City Plan: the High-level Talent Promotion and Training Project of Kunming (2022SCP001), Key Research and Development Program of Yunnan province (202203AC100010), Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (ZDBS-LY-SM011), and Yunnan Fundamental Research Projects (202401CF070061).

Received Date: 2025-11-24
Accepted Date: 2026-03-04
Rev Recd Date: 2026-03-02
Publish Date: 2026-03-11

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