Deep sequencing reveals <i>SLC35A2</i> somatic variants in MOGHE: molecular and clinical insights

Huaxia Luo; Xiaoqin Ruan; Xianyu Liu; Qingzhu Liu; Yu Sun; Yao Wang; Jixin Zhang; Lixin Cai; Yuwu Jiang; Ye Wu

doi:10.1016/j.jgg.2025.04.002

Volume 52 Issue 10

Oct. 2025

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Deep sequencing reveals SLC35A2 somatic variants in MOGHE: molecular and clinical insights

doi: 10.1016/j.jgg.2025.04.002

1. Children's Medical Center, Peking University First Hospital, Beijing 102627, China;
2. Pediatric Epilepsy Center, Peking University First Hospital, Beijing 102627, China;
3. Department of Pathology, Peking University First Hospital, Beijing 102627, China;
4. Pediatric Epilepsy Center, Peking University First Hospital, Beijing 102627, China;
5. Children's Medical Center, Peking University First Hospital, Beijing 102627, China;
6. Pediatric Epilepsy Center, Peking University First Hospital, Beijing 102627, China

Funds:

Development Foundation (YCXJ-JZ-2023-017), the National Natural Science Foundation of China (82171694, 81901155), National High Level Hospital Clinical Research Funding (High Quality Clinical Research Project of Peking University First Hospital) (23cz020202), National High Level Hospital Clinical Research Funding (Youth Clinical Research Project of Peking University First Hospital) (2023YC19), and National High Level Hospital Clinical Research Funding (Scientific Research Seed Fund of Peking University First Hospital) (2023SF42). The sponsors did not have any role in the study design, the collection, analysis, and interpretation of data, the writing of the report, or the decision to submit the work for publication.

We thank the participants for contributing their samples for our study. We also acknowledge the support from the High-performance Computing Platform of Peking University.This study received support from the following grants: the Natural Science Foundation of Beijing Municipality (7242149, L202034, 7244416), the E-Town Cooperation &

Received Date: 2025-02-17
Accepted Date: 2025-04-03
Rev Recd Date: 2025-04-02
Publish Date: 2025-04-10

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References

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