Tongue-coating microbiome reflects cardiovascular health and determines outcome in blood pressure intervention

Hairong Chen; Yue Ma; Min Li; Qingwei Li; Mengya Zhang; Zixiong Wang; Hongmei Liu; Jun Wang; Xiaolin Tong; Yixin Zeng

doi:10.1016/j.jgg.2023.01.003

Volume 50 Issue 10

Oct. 2023

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Tongue-coating microbiome reflects cardiovascular health and determines outcome in blood pressure intervention

doi: 10.1016/j.jgg.2023.01.003

1. CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;
2. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China;
3. Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China;
4. CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;
5. University of Chinese Academy of Sciences, Beijing 100049, China;
6. Rehabilitation Hospital Affiliated to National Rehabilitation Aids Research Center, Beijing 100176, China;
7. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China;
8. Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China;
9. CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China

Funds:

This work was supported by the Key Research Program of the Chinese Academy of Sciences under Grant KJZD-SW-L05 to Yixin Zeng and KJZD-SW-L05-04 to Hairong Chen, and the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine (Nos.ZYYCXTD-D-202001) to Jun Wang.

Received Date: 2022-11-08
Accepted Date: 2023-01-03
Rev Recd Date: 2022-12-21
Publish Date: 2023-01-19

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References

Avery, E.G., Bartolomaeus, H., Maifeld, A., Marko, L., Wiig, H., Wilck, N., Rosshart, S.P., Forslund, S.K.,Muller, D.N., 2021. The gut microbiome in hypertension recent advances and future perspectives. Circ. Res. 128, 934-950.

Barbadoro, P., Ponzio, E., Coccia, E., Prospero, E., Santarelli, A., Rappelli, G.G.L.,D'Errico, M.M., 2021. Association between hypertension, oral microbiome and salivary nitric oxide: a case-control study. Nitric Oxide 106, 66-71.

Blekkenhorst, L.C., Lewis, J.R., Prince, R.L., Devine, A., Bondonno, N.P., Bondonno, C.P., Wood, L.G., Puddey, I.B., Ward, N.C., Croft, K.D., et al., 2018. Nitrate-rich vegetables do not lower blood pressure in individuals with mildly elevated blood pressure: a 4-wk randomized controlled crossover trial. Am. J. Clin. Nutr. 107, 894-908.

Bondonno, C.P., Croft, K.D.,Hodgson, J.M., 2016. Dietary nitrate, nitric oxide, and cardiovascular health. Crit Rev Food Sci 56, 2036-2052.

Chen, H.R., Li, Q.W., Li, M., Liu, S., Yao, C.S., Wang, Z.X., Zhao, Z.Y., Liu, P., Yang, F., Li, X.J., et al., 2021. Microbial characteristics across different tongue coating types in a healthy population. J. Oral Microbiol. 13, 1946316.

Gao, L., Xu, T.S., Huang, G., Jiang, S., Gu, Y.,Chen, F., 2018. Oral microbiomes: more and more importance in oral cavity and whole body. Protein Cell 9, 488-500.

Hyde, E.R., Andrade, F., Vaksman, Z., Parthasarathy, K., Jiang, H., Parthasarathy, D.K., Torregrossa, A.C., Tribble, G., Kaplan, H.B., Petrosino, J.F., et al., 2014. Metagenomic analysis of nitrate-reducing bacteria in the oral cavity: implications for nitric oxide homeostasis. PLoS One 9(3): e8865.

Irfan, M., Delgado, R.Z.R.,Frias-Lopez, J., 2020. The oral microbiome and cancer. Front. Immunol. 11: 591088.

Kapil, V., Khambata, R.S., Robertson, A., Caulfield, M.J.,Ahluwalia, A., 2015. Dietary nitrate provides sustained blood pressure lowering in hypertensive patients A randomized, phase 2, double-blind, placebo-controlled study. Hypertension 65, 320-327.

Kleinstein, S.E., Nelson, K.E.,Freire, M., 2020. Inflammatory networks linking oral microbiome with systemic health and disease. J. Dent. Res. 99, 1131-1139.

LaMonte, M.J., Gordon, J.H., Diaz-Moreno, P., Andrews, C.A., Shimbo, D., Hovey, K.M., Buck, M.J.,Wactawski-Wende, J., 2022. Oral microbiome is associated with incident hypertension among postmenopausal women. J. Am. Heart Assoc. 11: e021930.

Lupo, G.F.D., Rocchetti, G., Lucini, L., Lorusso, L., Manara, E., Bertelli, M., Puglisi, E.,Capelli, E., 2021. Potential role of microbiome in chronic fatigue syndrome/myalgic encephalomyelits (CFS/ME). Sci Rep-Uk 11: 7043.

Sato-Suzuki, Y., Washio, J., Wicaksono, D.P., Sato, T., Fukumoto, S.,Takahashi, N., 2020. Nitrite-producing oral microbiome in adults and children. Sci Rep-Uk 10: 16652.

Vanhatalo, A., Blackwell, J.R., L'Heureux, J.E., Williams, D.W., Smith, A., van der Giezen, M., Winyard, P.G., Kelly, J.,Jones, A.M., 2018. Nitrate-responsive oral microbiome modulates nitric oxide homeostasis and blood pressure in humans. Free Radical Biol. Med. 124, 21-30.

Wang, T.W., Yu, L., Xu, C., Pan, K.L., Mo, M.L., Duan, M.X., Zhang, Y.,Xiong, H.Y., 2018. Chronic fatigue syndrome patients have alterations in their oral microbiome composition and function. PLoS One 13(9): e0203503.

Wang, Z.N., Klipfell, E., Bennett, B.J., Koeth, R., Levison, B.S., Dugar, B., Feldstein, A.E., Britt, E.B., Fu, X.M., Chung, Y.M., et al., 2011. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 472, 57-63.

Willis, J.R.,Gabaldon, T., 2020. The human oral microbiome in health and disease: from sequences to ecosystems. Microorganisms 8(2), 308.

Yan, Y.X., Liu, Y.Q., Li, M., Hu, P.F., Guo, A.M., Yang, X.H., Qiu, J.J., Yang, S.S., Shen, J., Zhang, L.P., et al., 2009. Development and evaluation of a questionnaire for measuring suboptimal health status in urban Chinese. J. Epidemiol. 19, 333-341.

Zhang, L., Wang, Y.A., Li, Y., Li, L.L., Xu, S.W., Feng, X.J.,Liu, S., 2018. Hydrogen sulfide (H₂S)-Releasing compounds: therapeutic potential in cardiovascular diseases. Front. Pharmacol. 9: 1066.

Zheng, W.W., Zhang, Z., Liu, C.H., Qiao, Y.Y., Zhou, D.R., Qu, J., An, H.J., Xiong, M., Zhu, Z.M.,Zhao, X.H., 2015. Metagenomic sequencing reveals altered metabolic pathways in the oral microbiota of sailors during a long sea voyage. Sci Rep-Uk 5: 9131.

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