9.9
CiteScore
7.1
Impact Factor
Turn off MathJax
Article Contents

SZDB3.0: an updated comprehensive resource and web tools for schizophrenia research

doi: 10.1016/j.jgg.2026.04.025
Funds:

This study was equally supported by the Brain Science and Brain-like Intelligence Technology-National Science and Technology Major Project (2025ZD0216000) and the Youth Science Fund Project (Category A) of the National Natural Science Foundation of China (Grant No. 82525026 to X.-J.L.). This study was also supported by the National Natural Science Foundation of China (No. 82401767, No. 82460289, No. 82301690, No. 82501799, and No. 82501798), Fund from Yunnan Province (202305AH340006), the startup funds from Southeast University (RF1028623032), and the SEU Innovation Capability Enhancement Plan for Doctoral Students (CXJH_SEU 25233).

  • Received Date: 2026-01-19
  • Accepted Date: 2026-04-29
  • Rev Recd Date: 2026-04-28
  • Available Online: 2026-05-13
  • loading
  • BrainSpan. 2013. BrainSpan: Atlas of the developing human brain. http://www.brainspan.org (accessed April 28 2015).
    Collado-Torres, L., Burke, E. E., Peterson, A., Shin, J., Straub, R. E., Rajpurohit, A., Semick, S. A., Ulrich, W. S., Price, A. J., Valencia, C., et al., 2019. Regional heterogeneity in gene expression, regulation, and coherence in the frontal cortex and hippocampus across development and schizophrenia. Neuron 103, 203-216.
    Dai, S., Dang, X., Gong, D., Li, D., Mu, C., Teng, Z., Luo, X.J., 2026. Molecular regulatory mechanisms of schizophrenia-associated functional non-coding variants. Mol. Psychiatry. doi: 10.1038/s41380-026-03566-8.
    Dang, X., Teng, Z., Yang, Y., Li, W., Liu, J., Hui, L., Zhou, D., Gong, D., Dai, S.-S., Li, Y., et al., 2025. Gene-level analysis reveals the genetic aetiology and therapeutic targets of schizophrenia. Nat. Hum. Behav. 9, 609-624.
    Dong, S., Zhao, N., Spragins, E., Kagda, M. S., Li, M., Assis, P., Jolanki, O., Luo, Y., Cherry, J. M., Boyle, A. P., et al., 2023. Annotating and prioritizing human non-coding variants with RegulomeDB v.2. Nat. Genet. 55, 724-726.
    Emani, P. S., Liu, J. J., Clarke, D., Jensen, M., Warrell, J., Gupta, C., Meng, R., Lee, C. Y., Xu, S., Dursun, C., et al., 2024. Single-cell genomics and regulatory networks for 388 human brains. Science 384, eadi5199.
    Fromer, M., Roussos, P., Sieberts, S. K., Johnson, J. S., Kavanagh, D. H., Perumal, T. M., Ruderfer, D. M., Oh, E. C., Topol, A., Shah, H. R., et al., 2016. Gene expression elucidates functional impact of polygenic risk for schizophrenia. Nat. Neurosci. 19, 1442-1453.
    Gandal, M. J., Zhang, P., Hadjimichael, E., Walker, R. L., Chen, C., Liu, S., Won, H., van Bakel, H., Varghese, M., Wang, Y., et al., 2018. Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder. Science 362, eaat8127.
    Huttlin, E. L., Bruckner, R. J., Navarrete-Perea, J., Cannon, J. R., Baltier, K., Gebreab, F., Gygi, M. P., Thornock, A., Zarraga, G., Tam, S., et al., 2021. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 184, 3022-3040.e3028.
    Kamburov, A., & Herwig, R., 2021. ConsensusPathDB 2022: molecular interactions update as a resource for network biology. Nucleic Acids Res. 50, D587-D595.
    Kim, C. Y., Baek, S., Cha, J., Yang, S., Kim, E., Marcotte, E. M., Hart, T., & Lee, I., 2022. HumanNet v3: an improved database of human gene networks for disease research. Nucleic Acids Res. 50, D632-D639.
    Lee, S., McAfee, J. C., Lee, J., Gomez, A., Ledford, A. T., Clarke, D., Min, H., Gerstein, M. B., Boyle, A. P., Sullivan, P. F., et al., 2025. Massively parallel reporter assay investigates shared genetic variants of eight psychiatric disorders. Cell 188, 1409-1424.
    McAfee, J. C., Lee, S., Lee, J., Bell, J. L., Krupa, O., Davis, J., Insigne, K., Bond, M. L., Zhao, N., Boyle, A. P., et al., 2023. Systematic investigation of allelic regulatory activity of schizophrenia-associated common variants. Cell Genom. 3, 100404.
    Qi, T., Wu, Y., Fang, H., Zhang, F., Liu, S., Zeng, J., & Yang, J., 2022. Genetic control of RNA splicing and its distinct role in complex trait variation. Nat. Genet. 54, 1355-1363.
    Qi, T., Wu, Y., Zeng, J., Zhang, F., Xue, A., Jiang, L., Zhu, Z., Kemper, K., Yengo, L., Zheng, Z., et al., 2018. Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood. Nat. Commun. 9, 2282.
    Trubetskoy, V., Pardinas, A. F., Qi, T., Panagiotaropoulou, G., Awasthi, S., Bigdeli, T. B., Bryois, J., Chen, C. Y., Dennison, C. A., Hall, L. S., et al., 2022. Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature 604, 502-508.
    Wang, D., Li, D., Dang, X., Mu, C., Liu, C., Zeng, Y., Yuan, Y., Teng, Z., Li, Y., & Luo, X. J., 2025. Mendelian randomization reveals causalities between DNA methylation and schizophrenia. Biol. Psychiatry 98, 712-723.
    Wu, Y., Li, X., Liu, J., Luo, X.-J., & Yao, Y.-G., 2020. SZDB2.0: an updated comprehensive resource for schizophrenia research. Hum. Genet. 139, 1285-1297.
    Wu, Y., Yao, Y. G., & Luo, X. J., 2017. SZDB: a database for schizophrenia genetic research. Schizophr. Bull. 43, 459-471.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (24) PDF downloads (0) Cited by ()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return