Recent advances in UVR8-mediated signal transduction

Jingzhen Liu; Zhiwei Zhao; Hongtao Liu

doi:10.1016/j.jgg.2026.04.005

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Recent advances in UVR8-mediated signal transduction

doi: 10.1016/j.jgg.2026.04.005

a. Guangdong Provincial Key Laboratory for Plant Epigenetics, Shenzhen Key Laboratory of High-Efficiency Utilization of Light in Plants, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China;
b. National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiol. and Ecology, Chinese Academy of Sciences, Shanghai 200032, China;
c. University of Chinese Academy of Sciences, Shanghai 200032, China

Funds:

We apologize to any authors whose work has not been cited due to space constraints. This work was supported in part by the National Key R&

D Program of China (2024YFA1306700), the National Natural Science Foundation of China (32330006, 32530011, 32150007), Research Team Cultivation Program of Shenzhen University (2023DFT005 to H.L.), Shenzhen Science and Technology Program(SYSRD20250529112700001), the research fund from Synthetic Biology Research Center of Shenzhen University.

Received Date: 2026-03-06
Accepted Date: 2026-04-08
Rev Recd Date: 2026-04-07

Available Online: 2026-04-15

Abstract

Abstract

Ultraviolet-B (UV-B) radiation (280-315 nm) is an essential component of sunlight that modulates various biological processes in plants. As the plant-specific UV-B photoreceptor, UV Resistance Locus 8 (UVR8) serves as the core molecule mediating UV-B signal perception and transduction in plants, playing a crucial role in regulating plant photomorphogenesis and stress adaptation. The canonical UVR8 pathway has been well characterized: upon UV-B perception, UVR8 undergoes dimer to monomer, accumulates in the nucleus, and then interacts with functional proteins to regulate gene transcription or other modification processes. However, recent studies have revealed non-canonical functions of UVR8, and its functions are not only evolutionarily conserved but also exhibit species-specific characteristics across different organisms. This review systematically summarizes recent progress in UVR8-mediated signal transduction, focusing on two core aspects: (1) the expanding spectrum of UVR8-interacting proteins and their functional roles; (2) evolutionary conservation and species-specific adaptations of UVR8 signaling. We also highlight unresolved key questions in UVR8 signal transduction, aiming to provide a reference for future mechanistic research and crop breeding applications.
- UV-B,
- UVR8,
- Photoreceptor,
- Interacting proteins,
- Crop adaptation

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References

Abramova, A., Vereshchagin, M., Kulkov, L., Kreslavski, V. D., Kuznetsov, V. V., Pashkovskiy, P., 2023. Potential role of phytochromes A and B and cryptochrome 1 in the adaptation of solanum lycopersicum to UV-B radiation. Int. J. Mol. Sci. 24, 13142.

Allorent, G., Lefebvre-Legendre, L., Chappuis, R., Kuntz, M., Truong, T. B., Niyogi, K. K., Ulm, R., Goldschmidt-Clermont, M., 2016. UV-B photoreceptor-mediated protection of the photosynthetic machinery in Chlamydomonas reinhardtii. Proc. Natl. Acad. Sci. U. S. A. 113, 14864-14869.

Almoguera, C., Prieto-Dapena, P., Personat, J. M., Tejedor-Cano, J., Lindahl, M., Diaz-Espejo, A., Jordano, J., 2012. Protection of the photosynthetic apparatus from extreme dehydration and oxidative stress in seedlings of transgenic tobacco. PLoS One 7, e51443.

Banerjee, S., Agarwal, P., Choudhury, S. R., Roy, S., 2024. MYB4, a member of R2R3-subfamily of MYB transcription factor functions as a repressor of key genes involved in flavonoid biosynthesis and repair of UV-B induced DNA double strand breaks in Arabidopsis. Plant Physiol. Biochem. 211, 108698.

Binkert, M., Kozma-Bognar, L., Terecskei, K., De Veylder, L., Nagy, F., Ulm, R., 2014. UV-B-responsive association of the Arabidopsis bZIP transcription factor ELONGATED HYPOCOTYL5 with target genes, including its own promoter. Plant Cell 26, 4200-4213.

Briggs, W. R., Christie, J. M., 2002. Phototropins 1 and 2: versatile plant blue-light receptors. Trends Plant Sci. 7, 204-210.

Brown, B. A., Cloix, C., Jiang, G. H., Kaiserli, E., Herzyk, P., Kliebenstein, D. J., Jenkins, G. I., 2005. A UV-B-specific signaling component orchestrates plant UV protection. Proc. Natl. Acad. Sci. U. S. A. 102, 18225-18230.

Carranco, R., Espinosa, J. M., Prieto-Dapena, P., Almoguera, C., Jordano, J., 2010. Repression by an auxin/indole acetic acid protein connects auxin signaling with heat shock factor-mediated seed longevity. Proc. Natl. Acad. Sci. U. S. A. 107, 21908-21913.

Carranco, R., Prieto-Dapena, P., Almoguera, C., Jordano, J., 2022. A seed-specific transcription factor, HSFA9, anticipates UV-B light responses by mimicking the activation of the UV-B receptor in tobacco. Plant J. 111, 1439-1452.

Cashmore, A. R., Jarillo, J.A., Wu, Y.-J., Liu, D., 1999. Cryptochromes: blue light receptors for plants and animals. Science 284, 760-765.

Chaves, I., Pokorny, R., Byrdin, M., Hoang, N., Ritz, T., Brettel, K., Essen, L. O., van der Horst, G. T., Batschauer, A., Ahmad, M., 2011. The cryptochromes: blue light photoreceptors in plants and animals. Annu. Rev. Plant Biol. 62, 335-364.

Che, J, Zhang Q., Li G., Xie B., Xie S., Zhao C., Zhang K., Liu X., 2023. Identification and expression analysis of UV-B photoreceptor UVR8 genes in Apocynum venetum and A. cannabinum. Guihaia 43, 1876-1891(in Chinese).zh.

Chen, H., Han, R., 2016. Characterization of actin filament dynamics during mitosis in Wheat protoplasts under UV-B radiation. Sci. Rep. 6, 20115.

Chen, H., Yin, Y., Niu, J., Kwak, J. M., Du, M., Elzenga, J. T. M., 2023. Analysis of Brachypodium distachyon UVR8 reveals conservation in UV-B receptors. Plant Biol. (Stuttg.) 25, 750-756.

Chen, J., Xu, H., Liu, Q., Ke, M., Zhang, Z., Wang, X., Gao, Z., Wu, R., Yuan, Q., Qian, C., et al., 2024a. Shoot-to-root communication via GmUVR8-GmSTF3 photosignaling and flavonoid biosynthesis fine-tunes soybean nodulation under UV-B light. New Phytol. 241, 209-226.

Chen, S., Podolec, R., Arongaus, A. B., Fuchs, C., Loubery, S., Demarsy, E., Ulm, R., 2024b. Functional divergence of Arabidopsis REPRESSOR OF UV-B PHOTOMORPHOGENESIS 1 and 2 in repression of flowering. Plant Physiol. 194, 1563-1576.

Chen, Y. L., Zhong, Y. B., Leung, D. W. M., Yan, X. Y., Ouyang, M. N., Ye, Y. Z., Li, S. M., Peng, X. X., Liu, E. E., 2024c. OsUVR8b, rather than OsUVR8a, plays a predominant role in rice UVR8-mediated UV-B response. Physiol. Plant. 176, e14471.

Chen, Z., Dong, Y., Huang, X., 2022. Plant responses to UV-B radiation: signaling, acclimation and stress tolerance. Stress Biol. 2, 51.

Cheng, Z., Zhang, X., Huang, P., Huang, G., Zhu, J., Chen, F., Miao, Y., Liu, L., Fu, Y. F., Wang, X., 2020. Nup96 and HOS1 are mutually stabilized and gate CONSTANS protein level, conferring long-day photoperiodic flowering regulation in Arabidopsis. Plant Cell 32, 374-391.

Chouhan, S., Chauhan, K., Kataria, S., Kn, G., 2008. Enhancement in leghemoglobin content of root nodules by exclusion of solar UV-A and UV-B radiation in soybean. J. Plant Biol. 51, 132-138.

Christie, J. M., 2007. Phototropin blue-light receptors. Annu. Rev. Plant Biol. 58, 21-45.

Christie, J. M., Arvai, A. S., Baxter, K. J., Heilmann, M., Pratt, A. J., O'Hara, A., Kelly, S. M., Hothorn, M., Smith, B. O., Hitomi, K., et al., 2012. Plant UVR8 photoreceptor senses UV-B by tryptophan-mediated disruption of cross-dimer salt bridges. Science 335, 1492-1496.

Clayton, W. A., Albert, N. W., Thrimawithana, A. H., McGhie, T. K., Deroles, S. C., Schwinn, K. E., Warren, B. A., McLachlan, A. R. G., Bowman, J. L., Jordan, B. R., et al., 2018. UVR8-mediated induction of flavonoid biosynthesis for UVB tolerance is conserved between the liverwort Marchantia polymorpha and flowering plants. Plant J. 96, 503-517.

Cun, S., Zhang, C., Chen, J., Qian, L., Sun, H., Song, B., 2024. Effects of UV-B radiation on pollen germination and tube growth: A global meta-analysis. Sci. Total Environ. 915, 170097.

Cunningham, N., Crestani, G., Csepregi, K., Coughlan, N. E., Jansen, M. A. K., 2024. Exploring the complexities of plant UV responses; distinct effects of UV-A and UV-B wavelengths on Arabidopsis rosette morphology. Photochem. Photobiol. Sci. 23, 1251-1264.

Del Casino, C., Conti, V., Licata, S., Cai, G., Cantore, A., Ricci, C., Cantara, S., 2024. Mitigation of UV-B Radiation Stress in Tobacco Pollen by Expression of the Tardigrade Damage Suppressor Protein (Dsup). Cells 13, 840.

Deng, G., Sun, H., Hu, Y., Yang, Y., Li, P., Chen, Y., Zhu, Y., Zhou, Y., Huang, J., Neill, S. J., et al., 2023. A transcription factor WRKY36 interacts with AFP2 to break primary seed dormancy by progressively silencing DOG1 in Arabidopsis. New Phytol. 238, 688-704.

Diffey, B. L., 2002. Sources and measurement of ultraviolet radiation. Methods 28, 4-13.

Dillon, F. M., Tejedor, M. D., Ilina, N., Chludil, H. D., Mithofer, A., Pagano, E. A., Zavala, J. A., 2018. SolarUV-Bradiation and ethylene play a key role in modulating effective defenses against Anticarsia gemmatalislarvae in field-grown soybean. Plant Cell Environ. 41, 383-394.

Fang, F., Lin, L., Zhang, Q., Lu, M., Skvortsova, M. Y., Podolec, R., Zhang, Q., Pi, J., Zhang, C., Ulm, R., et al., 2022. Mechanisms of UV-B light-induced photoreceptor UVR8 nuclear localization dynamics. New Phytol. 236, 1824-1837.

Favory, J. J., Stec, A., Gruber, H., Rizzini, L., Oravecz, A., Funk, M., Albert, A., Cloix, C., Jenkins, G. I., Oakeley, E. J., et al., 2009. Interaction of COP1 and UVR8 regulates UV-B-induced photomorphogenesis and stress acclimation in Arabidopsis. EMBO J. 28, 591-601.

Feher, B., Kozma-Bognar, L., Kevei, E., Hajdu, A., Binkert, M., Davis, S. J., Schafer, E., Ulm, R., Nagy, F., 2011. Functional interaction of the circadian clock and UV RESISTANCE LOCUS 8-controlled UV-B signaling pathways in Arabidopsis thaliana. Plant J. 67, 37-48.

Fernandez, M. B., Lamattina, L., Cassia, R., 2020. Functional analysis of the UVR8 photoreceptor from the monocotyledonous Zea mays. Plant Growth Regul. 92, 307-318.

Findlay, K. M. W., Jenkins, G. I., 2016. Regulation of UVR8 photoreceptor dimer/monomer photo-equilibrium in Arabidopsis plants grown under photoperiodic conditions. Plant Cell Environ. 39, 1706-1714.

Friedman, M., 2002. Tomato glycoalkaloids: Role in the plant and in the diet. J. Agric. Food Chem. 50, 5751-5780.

Fukuda, S., Satoh, A., Kasahara, H., Matsuyama, H., Takeuchi, Y., 2008. Effects of ultraviolet-b irradiation on the cuticular wax of cucumber (Cucumis sativus) cotyledons. J. Plant Res. 121, 179-189.

Gangappa, S. N., Botto, J. F., 2016. The multifaceted roles of HY5 in plant growth and development. Mol Plant 9, 1353-1365.

Gruber, H., Heijde, M., Heller, W., Albert, A., Seidlitz, H. K., Ulm, R., 2010. Negative feedback regulation of UV-B-induced photomorphogenesis and stress acclimation in Arabidopsis. Proc. Natl. Acad. Sci. U. S. A.107, 20132-20137.

Han, S.-H., Ji, M. G., Kim, W.-Y., Park, C.-M., Jung, J.-H., 2025. A nuclear pore complex component HOS1 mediates UV-B light-induced UVR8 nuclear localization for activating HY5 cascade in Arabidopsis. bioRxiv, 2025.09.22.677739. doi: https://doi.org/10.1101/.

Heijde, M., Ulm, R., 2013. Reversion of the Arabidopsis UV-B photoreceptor UVR8 to the homodimeric ground state. Proc. Natl. Acad. Sci. U. S. A.110, 1113-1118.

Heilmann, M., Jenkins, G. I., 2013. Rapid Reversion from Monomer to Dimer Regenerates the Ultraviolet-B Photoreceptor UV RESISTANCE LOCUS8 in Intact Arabidopsis Plants. Plant Physiol. 161, 547-555.

Heilmann, M., Velanis, C. N., Cloix, C., Smith, B. O., Christie, J. M., Jenkins, G. I., 2016. Dimer/monomer status and in vivo function of salt-bridge mutants of the plant UV-B photoreceptor UVR8. Plant J. 88, 71-81.

Hu, S., Chen, Y., Qian, C., Ren, H., Liang, X., Tao, W., Chen, Y., Wang, J., Dong, Y., Han, J., et al., 2024. Nuclear accumulation of rice UV-B photoreceptors is UV-B- and OsCOP1-independent for UV-B responses. Nat. Commun. 15, 6396.

Huang, X., Ouyang, X., Yang, P., Lau, O. S., Chen, L., Wei, N., Deng, X. W., 2013. Conversion from CUL4-based COP1-SPA E3 apparatus to UVR8-COP1-SPA complexes underlies a distinct biochemical function of COP1 under UV-B. Proc. Natl. Acad. Sci. U. S. A.110, 16669-16674.

Huang, X., Ouyang, X., Yang, P., Lau, O. S., Li, G., Li, J., Chen, H., Deng, X. W., 2012. Arabidopsis FHY3 and HY5 positively mediate induction of COP1 transcription in response to photomorphogenic UV-B light. Plant Cell 24, 4590-4606.

Idris, M., Seo, N., Jiang, L., Kiyota, S., Hidema, J., Iino, M., 2021. UV-B signalling in rice: Response identification, gene expression profiling and mutant isolation. Plant Cell Environ. 44, 1468-1485.

Jenkins, G. I., 2009. Signal Transduction in Responses to UV-B Radiation. Annu. Rev. Plant Biol. 60, 407-431.

Jiang, J., Liu, J., Sanders, D., Qian, S., Ren, W., Song, J., Liu, F., Zhong, X., 2021. UVR8 interacts with de novo DNA methyltransferase and suppresses DNA methylation in Arabidopsis. Nat. Plants 7, 184-197.

Jiang, L., Wang, Y., Li, Q.-F., Bjorn, L. O., He, J.-X., Li, S.-S., 2012. Arabidopsis STO/BBX24 negatively regulates UV-B signaling by interacting with COP1 and repressing HY5 transcriptional activity. Cell Res. 22, 1046-1057.

Jiang, N., Garcia Navarrete, T., Lee, Y. S., Pawlowski, E. G., Park, S., Grotewold, E., 2025. Flavonoid pathway intermediates implicate UVR8 in functions beyond canonical UV-B signaling. Nat. Commun. 16, 7810.

Johnson, L. M., Law, J. A., Khattar, A., Henderson, I. R., Jacobsen, S. E., 2008. SRA-domain proteins required for DRM2-mediated de novo DNA methylation. PLoS Genet. 4, e1000280.

Kaiserli, E., Jenkins, G. I., 2007. UV-B promotes rapid nuclear translocation of the Arabidopsis UV-B specific signaling component UVR8 and activates its function in the nucleus. Plant Cell 19, 2662-2673.

Kang, Q., Wang, X., Shen, M.-y., Xu, J.-t., Chen, S.-l., Liao, P.-Y., Xu, W.-Z., Wu, W., Xu, D.-B., 2025. Cloning and Expression Analysis of the UV-B Receptor Gene McUVR8 in Mentha canadensis L.[J]. Biotechnol. Bull. 41, 255-266.

Kim, J. H., Nguyen, N. H., Jeong, C. Y., Nguyen, N. T., Hong, S. W., Lee, H., 2013. Loss of the R2R3 MYB, AtMyb73, causes hyper-induction of the SOS1 and SOS3 genes in response to high salinity in Arabidopsis. J. Plant Physiol. 170, 1461-1465.

Kliebenstein, D. J., Lim, J. E., Landry, L. G., Last, R. L., 2002. Arabidopsis UVR8 regulates ultraviolet-b signal transduction and tolerance and contains sequence similarity to human regulator of chromatin condensation 1. Plant Physiol. 130, 234-243.

Kondou, Y., Miyagi, Y., Morito, T., Fujihira, K., Miyauchi, W., Moriyama, A., Terasawa, T., Ishida, S., Iwabuchi, K., Kubo, H., et al., 2019. Physiological function of photoreceptor UVR8 in UV-B tolerance in the liverwort Marchantia polymorpha. Planta 249, 1349-1364.

Koti, S., Reddy, K. R., Reddy, V. R., Kakani, V. G., Zhao, D., 2005. Interactive effects of carbon dioxide, temperature, and ultraviolet-B radiation on soybean (Glycine max L.) flower and pollen morphology, pollen production, germination, and tube lengths. J. Exp. Bot. 56, 725-736.

Lau, K., Podolec, R., Chappuis, R., Ulm, R., Hothorn, M., 2019. Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. EMBO J. 38, e102140.

Lau, O. S., Deng, X. W., 2012. The photomorphogenic repressors COP1 and DET1: 20 years later. Trends Plant Sci. 17, 584-593.

Leasure, C. D., Tong, H., Yuen, G., Hou, X., Sun, X., He, Z.-H., 2009. ROOT UV-B SENSITIVE2 acts with ROOT UV-B SENSITIVE1 in a root ultraviolet B-sensing pathway. Plant Physiol. 150, 1902-1915.

Li, C., Du, J., Xu, H., Feng, Z., Chater, C. C. C., Duan, Y., Yang, Y., Sun, X., 2024a. UVR8-TCP4-LOX2 module regulates UV-B tolerance in Arabidopsis. J. Integr. Plant Biol. 66, 897-908.

Li, H., Li, Y., Deng, H., Sun, X., Wang, A., Tang, X., Gao, Y., Zhang, N., Wang, L., Yang, S., et al., 2018a. Tomato UV-B receptor SlUVR8 mediates plant acclimation to UV-B radiation and enhances fruit chloroplast development via regulating SlGLK2. Sci. Rep. 8, 6097.

Li, L., Jiang, G., Li, H., Liu, J., Zhang, P., Wang, Q., Huang, L., Zhang, S., Wang, X., Zhang, L., et al., 2024b. UV-B induced flavonoid accumulation and related gene expression in blue- grained wheat at different periods of time. Front. Plant Sci. 15, 1520543.

Li, X., Ma, M., Shao, W., Wang, H., Fan, R., Chen, X., Wang, X., Zhan, Y., Zeng, F., 2018b. Molecular cloning and functional analysis of a UV-B photoreceptor gene, BpUVR8 (UV Resistance Locus 8), from birch and its role in ABA response. Plant Sci. 274, 294-308.

Li, Y., Du, Y., Huai, J., Jing, Y., Lin, R., 2022. The RNA helicase UAP56 and the E3 ubiquitin ligase COP1 coordinately regulate alternative splicing to repress photomorphogenesis in Arabidopsis. Plant Cell 34, 4191-4212.

Liang, T., Mei, S., Shi, C., Yang, Y., Peng, Y., Ma, L., Wang, F., Li, X., Huang, X., Yin, Y., et al., 2018. UVR8 Interacts with BES1 and BIM1 to Regulate Transcription and Photomorphogenesis in Arabidopsis. Dev. Cell 44, 512-523.e515.

Liang, T., Shi, C., Peng, Y., Tan, H., Xin, P., Yang, Y., Wang, F., Li, X., Chu, J., Huang, J., et al., 2020. Brassinosteroid-activated BRI1-EMS-SUPPRESSOR 1 inhibits flavonoid biosynthesis and coordinates growth and UV-B stress responses in plants. Plant Cell 32, 3224-3239.

Liang, T., Yang, Y., Liu, H., 2019. Signal transduction mediated by the plant UV-B photoreceptor UVR8. New Phytol. 221, 1247-1252.

Liang, Y., Podolec, R., Chappuis, R., Defossez, E., Glauser, G., Rotzer, J., Stolze, S. C., Dolan, L., Nakagami, H., Demarsy, E., et al., 2025. Conservation and divergence of UVR8-COP1/SPA-HY5 signaling in UV-B responses of Marchantia polymorpha. bioRxiv, 2025.07.16.665153. doi: https://doi.org/10.1101/.

Liao, X., Jenkins, G. I., 2022. Cysteines have a role in conformation of the UVR8 photoreceptor. Plant J. 111, 583-594.

Ling, C., Wang, X., Li, Z., He, Y., Li, Y., 2022. Effects and mechanism of enhanced UV-B radiation on the flag leaf angle of rice. Int. J. Mol. Sci. 23, 12776.

Liu, H., Liu, B., Zhao, C., Pepper, M., Lin, C., 2011. The action mechanisms of plant cryptochromes. Trends Plant Sci. 16, 684-691.

Liu, J., Cheng, X., Liu, P., Li, D., Chen, T., Gu, X., Sun, J., 2017. Microrna319-regulated TCPs interact with FBHs and PFT1 to activate CO transcription and control flowering time in Arabidopsis. PLoS Genet. 13, e1006833.

Liu, L., Gregan, S., Winefield, C., Jordan, B., 2015. From UVR8 to flavonol synthase: UV-B-induced gene expression in Sauvignon blanc grape berry. Plant Cell Environ. 38, 905-919.

Liu, L.-J., Zhang, Y.-C., Li, Q.-H., Sang, Y., Mao, J., Lian, H.-L., Wang, L., Yang, H.-Q., 2008. COP1-mediated ubiquitination of CONSTANS is implicated in cryptochrome regulation of flowering in Arabidopsis. Plant Cell 20, 292-306.

Liu, M., Lin, X., Cao, K., Yang, L., Xu, H., Zhou, X., 2023. Multi-Omic analysis reveals the molecular mechanism of UV-B stress resistance in acetylated RcMYB44 in rhododendron chrysanthum. Genes 14, 2022.

Liu, W., Giuriani, G., Havlikova, A., Li, D., Lamont, D. J., Neugart, S., Velanis, C. N., Petersen, J., Hoecker, U., Christie, J. M., et al., 2024a. Phosphorylation of Arabidopsis UVR8 photoreceptor modulates protein interactions and responses to UV-B radiation. Nat. Commun. 15, 1221.

Liu, W., Jenkins, G. I., Datta, S., 2025a. Recent advances in UV-B signalling: interaction of proteins with the UVR8 photoreceptor. J. Exp. Bot. 76, 873-881.

Liu, X., Xie, Z., Xin, J., Yuan, S., Liu, S., Sun, Y., Zhang, Y., Jin, C., 2024b. OsbZIP18 is a positive regulator of phenylpropanoid and flavonoid biosynthesis under UV-B radiation in rice. Plants 13, 498.

Liu, X., Zhang, Q., Yang, G., Zhang, C., Dong, H., Liu, Y., Yin, R., Lin, L., 2020. Pivotal roles of Tomato photoreceptor SlUVR8 in seedling development and UV-B stress tolerance. Biochem. Biophys. Res. Commun. 522, 177-183.

Liu, Y., Wang, J., Liu, X., Liao, T., Ren, H., Liu, L., Huang, X., 2025b. The UV-B photoreceptor UVR8 interacts with the LOX1 enzyme to promote stomatal closure through the LOX-derived oxylipin pathway. Plant Cell 37, koaf060.

Liu, Y., Zhao, Z., Zhang, X., Hao, Y., Feng, F., Chen, Y., Wang, J., Ma, M., Li, J., Yu, F., et al., 2025c. Structural assembly of maize CRY-GL2 photosignaling complex provides insights into its regulatory role in cuticular wax biosynthesis. Sci Adv 11, eadz0136.

Loyola, R., Herrera, D., Mas, A., Wong, D. C. J., Holl, J., Cavallini, E., Amato, A., Azuma, A., Ziegler, T., Aquea, F., et al., 2016. The photomorphogenic factors UV-B RECEPTOR 1, ELONGATED HYPOCOTYL 5, and HY5 HOMOLOGUE are part of the UV-B signalling pathway in grapevine and mediate flavonol accumulation in response to the environment. J. Exp. Bot. 67, 5429-5445.

Ma, M., Wang, P., Yang, R., Zhou, T., Gu, Z., 2019. UV-B mediates isoflavone accumulation and oxidative-antioxidant system responses in germinating soybean. Food Chem. 275, 628-636.

Margalha, L., Elias, A., Belda-Palazon, B., Peixoto, B., Confraria, A., Baena-Gonzalez, E., 2023. HOS1 promotes plant tolerance to low-energy stress via the SnRK1 protein kinase. Plant J. 115, 627-641.

Moglich, A., Yang, X., Ayers, R. A., Moffat, K., 2010. Structure and function of plant photoreceptors. Annu. Rev. Plant Biol. 61, 21-47.

Montillet, J. L., Leonhardt, N., Mondy, S., Tranchimand, S., Rumeau, D., Boudsocq, M., Garcia, A. V., Douki, T., Bigeard, J., Lauriere, C., et al., 2013. An abscisic acid-independent oxylipin pathway controls stomatal closure and immune defense in Arabidopsis. PLoS Biol. 11, e1001513.

Neugart, S., Steininger, V., Fernandes, C., Martinez-Abaigar, J., Nunez-Olivera, E., Schreiner, M., Strid, A., Viczian, A., Albert, A., Badenes-Perez, F. R., et al., 2024. A synchronized, large-scale field experiment using Arabidopsis thaliana reveals the significance of the UV-B photoreceptor UVR8 under natural conditions. Plant Cell Environ. 47, 4031-4047.

Nisar, S., Raza, Z. A., 2024. Corn straw lignin - A sustainable bioinspired finish for superhydrophobic and UV-protective cellulose fabric. Int. J. Biol. Macromol. 257, 128393.

O’Hara, A., Headland, L. R., Diaz-Ramos, L. A., Morales, L. O., Strid, A., Jenkins, G. I., 2019. Regulation of Arabidopsis gene expression by low fluence rate UV-B independently of UVR8 and stress signaling. Photochem. Photobiol. Sci. 18, 1675-1684.

O’Hara, A., Jenkins, G. I., 2012. In Vivo Function of Tryptophans in the Arabidopsis UV-B Photoreceptor UVR8. Plant Cell 24, 3755-3766.

Oravecz, A., Baumann, A., Mate, Z., Brzezinska, A., Molinier, J., Oakeley, E. J., Adam, E., Schafer, E., Nagy, F., Ulm, R., 2006. CONSTITUTIVELY PHOTOMORPHOGENIC1 is required for the UV-B response in Arabidopsis. Plant Cell 18, 1975-1990.

Palma, C. F. F., Castro-Alves, V., Rosenqvist, E., Ottosen, C. O., Strid, A., Morales, L. O., 2021. Effects of UV radiation on transcript and metabolite accumulation are dependent on monochromatic light background in cucumber. Physiol. Plant. 173, 750-761.

Peng, Q., Zhou, Q., 2010. Effects of enhanced UV-B radiation on the distribution of mineral elements in soybean (Glycine max) seedlings. Chemosphere 78, 859-863.

Pham, V. N., Kathare, P. K., Huq, E., 2018. Dynamic regulation of PIF5 by COP1-SPA complex to optimize photomorphogenesis in Arabidopsis. Plant J. 96, 260-273.

Pinto, M. E., Edwards, G. E., Riquelme, A. A., Ku, M. S. B., 2002. Enhancement of nodulation in bean (Phaseolus vulgaris) by UV-B irradiation. Funct. Plant Biol. 29, 1189-1196.

Podolec, R., Wagnon, T. B., Leonardelli, M., Johansson, H., Ulm, R., 2022. Arabidopsis B-box transcription factors BBX20-22 promote UVR8 photoreceptor-mediated UV-B responses. Plant J. 111, 422-439.

Ponnu, J., Riedel, T., Penner, E., Schrader, A., Hoecker, U., 2019. Cryptochrome 2 competes with COP1 substrates to repress COP1 ubiquitin ligase activity during Arabidopsis photomorphogenesis. Proc. Natl. Acad. Sci. U. S. A. 116, 27133-27141.

Pradhan, M. K., Joshi, P. N., Nair, J. S., Ramaswamy, N. K., Iyer, R. K., Biswal, B., Biswal, U. C., 2006. UV-B exposure enhances senescence of wheat leaves: modulation by photosynthetically active radiation. Radiat. Environ. Biophys. 45, 221-229.

Qian, C., Chen, Z., Liu, Q., Mao, W., Chen, Y., Tian, W., Liu, Y., Han, J., Ouyang, X., Huang, X., 2020. Coordinated transcriptional regulation by the UV-B photoreceptor and multiple transcription factors for plant UV-B responses. Molecular Plant 13, 777-792.

Qian, C., Mao, W., Liu, Y., Ren, H., Lau, O. S., Ouyang, X., Huang, X., 2016. Dual-source nuclear monomers of UV-B light receptor direct photomorphogenesis in Arabidopsis. Mol Plant 9, 1671-1674.

Quail, P. H., 2002. Phytochrome photosensory signalling networks. Nat. Rev. Mol. Cell Biol. 3, 85-93.

Rai, N., O'Hara, A., Farkas, D., Safronov, O., Ratanasopa, K., Wang, F., Lindfors, A. V., Jenkins, G. I., Lehto, T., Salojarvi, J., et al., 2020. The photoreceptor UVR8 mediates the perception of both UV-B and UV-A wavelengths up to 350 nm of sunlight with responsivity moderated by cryptochromes. Plant Cell Environ 43, 1513-1527.

Rajendiran, K., Ramanujam, M. P., 2006. Interactive effects of UV-B irradiation and triadimefon on nodulation and nitrogen metabolism in Vigna radiata plants. Biol. Plant. 50, 709-712.

Renault, L., Nassar, N., Vetter, I., Becker, J., Klebe, C., Roth, M., Wittinghofer, A., 1998. The 1.7 A crystal structure of the regulator of chromosome condensation (RCC1) reveals a seven-bladed propeller. Nature 392, 97-101.

Rizzini, L., Favory, J. J., Cloix, C., Faggionato, D., O'Hara, A., Kaiserli, E., Baumeister, R., Schafer, E., Nagy, F., Jenkins, G. I., et al., 2011. Perception of UV-B by the Arabidopsis UVR8 protein. Science 332, 103-106.

Santin, M., Simoni, S., Vangelisti, A., Giordani, T., Cavallini, A., Mannucci, A., Ranieri, A., Castagna, A., 2023. Transcriptomic analysis on the peel of UV-B-exposed peach fruit reveals an upregulation of phenolic- and UVR8-related pathways. Plants (Basel, Switzerland) 12, 1818.

Schommer, C., Debernardi, J. M., Bresso, E. G., Rodriguez, R. E., Palatnik, J. F., 2014. Repression of cell proliferation by miR319-regulated TCP4. Mol Plant 7, 1533-1544.

Sharma, A., Sharma, B., Hayes, S., Kerner, K., Hoecker, U., Jenkins, G. I., Franklin, K. A., 2019. UVR8 disrupts stabilisation of PIF5 by COP1 to inhibit plant stem elongation in sunlight. Nat. Commun. 10, 4417.

Shen, L., Qi, X., Guo, Z., 2025. Wheat. Curr. Biol. 35, R1037-R1043. doi: 10.1016/j.cub.2025.09.007. PMID: 41187710.

Soriano, G., Cloix, C., Heilmann, M., Nunez-Olivera, E., Martinez-Abaigar, J., Jenkins, G. I., 2017. Evolutionary conservation of structure and function of the UVR8 photoreceptor from the liverwort Marchantia polymorpha and the moss Physcomitrella patens. New Phytol. 217, 151-162.

Subramanian, C., Kim, B. H., Lyssenko, N. N., Xu, X., Johnson, C. H., von Arnim, A. G., 2004. The Arabidopsis repressor of light signaling, COP1, is regulated by nuclear exclusion: mutational analysis by bioluminescence resonance energy transfer. Proc. Natl. Acad. Sci. U. S. A. 101, 6798-6802.

Sun, J., Huang, S., Lu, Q., Li, S., Zhao, S., Zheng, X., Zhou, Q., Zhang, W., Li, J., Wang, L., et al., 2023. UV-B irradiation-activated E3 ligase GmILPA1 modulates gibberellin catabolism to increase plant height in soybean. Nat. Commun. 14, 6262.

Tavridou, E., Pireyre, M., Ulm, R., 2020a. Degradation of the transcription factors PIF4 and PIF5 under UV-B promotes UVR8-mediated inhibition of hypocotyl growth in Arabidopsis. Plant J. 101, 507-517.

Tavridou, E., Schmid-Siegert, E., Fankhauser, C., Ulm, R., 2020b. UVR8-mediated inhibition of shade avoidance involves HFR1 stabilization in Arabidopsis. PLoS Genet. 16, e1008797.

Tian, C., Wang, Y., Yang, T., Sun, Q., Ma, M., Li, M., 2022. Evolution of physicochemical properties, phenolic acid accumulation, and dough-making quality of whole Wheat flour during germination under UV-B radiation. Front. Nutr. 9, 877324.

Tilbrook, K., Dubois, M., Crocco, C. D., Yin, R., Chappuis, R., Allorent, G., Schmid-Siegert, E., Goldschmidt-Clermont, M., Ulm, R., 2016. UV-B perception and acclimation in chlamydomonas reinhardtii. Plant Cell 28, 966-983.

Tissot, N., Ulm, R., 2020. Cryptochrome-mediated blue-light signalling modulates UVR8 photoreceptor activity and contributes to UV-B tolerance in Arabidopsis. Nat. Commun. 11, 1323.

Vicente, J., Cascon, T., Vicedo, B., Garcia-Agustin, P., Hamberg, M., Castresana, C., 2012. Role of 9-lipoxygenase and α-dioxygenase oxylipin pathways as modulators of local and systemic defense. Mol Plant 5, 914-928.

Wang, F., Xu, Z., Fan, X., Zhou, Q., Cao, J., Ji, G., Jing, S., Feng, B., Wang, T., 2019. Transcriptome analysis reveals complex molecular mechanisms underlying UV tolerance of Wheat (Triticum aestivum, L.). J. Agric. Food Chem. 67, 563-577.

Wang, J., 2025a. How UV-B-activated UVR8 triggers LOX1 to close stomata: unveiling a mechanism of photoreceptor-regulated enzyme activity in the cytoplasm. Plant Cell 37, koaf076. doi: 10.1093/plcell/koaf076. PMID: 40171605; PMCID: PMC12017390.

Wang, L., Qiu, T., Yue, J., Guo, N., He, Y., Han, X., Wang, Q., Jia, P., Wang, H., Li, M., et al., 2021. Arabidopsis ADF1 is regulated by MYB73 and is involved in response to salt stress affecting actin filament organization. Plant Cell Physiol. 62, 1387-1395.

Wang, L., Wang, Y., Chang, H., Ren, H., Wu, X., Wen, J., Guan, Z., Ma, L., Qiu, L., Yan, J., et al., 2023a. RUP2 facilitates UVR8 redimerization via two interfaces. Plant Commun. 4, 100428.

Wang, M., Liu, G., Guo, T., Xie, C., Wang, P., Yang, R., 2023b. UV-B radiation enhances isoflavone accumulation and antioxidant capacity of soybean calluses. Front. Nutr. 10, 1139698.

Wang, X., Zhi, P., Ge, P., Fu, Y., Liu, X., Chen, W., Chang, C., 2025b. HISTONE DEACETYLASE 19 interacts with ELONGATED HYPOCOTYL5 to regulate wheat cuticular wax biosynthesis in response to ultraviolet B radiation. Plant J. 123, e70395.

Wang, Y., Wang, L., Guan, Z., Chang, H., Ma, L., Shen, C., Qiu, L., Yan, J., Zhang, D., Li, J., et al., 2022. Structural insight into UV-B-activated UVR8 bound to COP1. Sci. Adv. 8, eabn3337.

Wu, D., Hu, Q., Yan, Z., Chen, W., Yan, C., Huang, X., Zhang, J., Yang, P., Deng, H., Wang, J., et al., 2012. Structural basis of ultraviolet-B perception by UVR8. Nature 484, 214-219.

Xiao, Y., Chu, L., Zhang, Y., Bian, Y., Xiao, J., Xu, D., 2021. HY5: A pivotal regulator of light-dependent development in higher plants. Front Plant Sci 12, 800989.

Xie, Y., Miao, T., Lyu, S., Huang, Y., Shu, M., Li, S., Xiong, T., 2024. Arabidopsis ERD15 regulated by BBX24 plays a positive role in UV-B signaling. Plant Sci. 343, 112077.

Xu, C., Huang, X., Ma, N., Liu, Y., Xu, A., Zhang, X., Li, D., Li, Y., Zhang, W., Wang, K., 2024. MicroRNA164 affects plant responses to UV radiation in perennial ryegrass. Plants 13, 1242.

Yang, Y., Liang, T., Zhang, L., Shao, K., Gu, X., Shang, R., Shi, N., Li, X., Zhang, P., Liu, H., 2018. UVR8 interacts with WRKY36 to regulate HY5 transcription and hypocotyl elongation in Arabidopsis. Nat. Plants 4, 98-107.

Yang, Y., Zhang, L., Chen, P., Liang, T., Li, X., Liu, H., 2020. UV-B photoreceptor UVR8 interacts with MYB73/MYB77 to regulate auxin responses and lateral root development. EMBO J. 39, e101928.

Yi, C., Deng, X. W., 2005. COP1 - from plant photomorphogenesis to mammalian tumorigenesis. Trends Cell Biol. 15, 618-625.

Yin, R., Arongaus, A. B., Binkert, M., Ulm, R., 2015. Two distinct domains of the UVR8 photoreceptor interact with COP1 to initiate UV-B signaling in Arabidopsis. Plant Cell 27, 202-213.

Yin, R., Skvortsova, M. Y., Loubery, S., Ulm, R., 2016. COP1 is required for UV-B-induced nuclear accumulation of the UVR8 photoreceptor. Proc. Natl. Acad. Sci. U. S. A.113, E4415-E4422.

Yin, R., Ulm, R., 2017. How plants cope with UV-B: from perception to response. Curr. Opin. Plant Biol. 37, 42-48.

Yin, Y., Vafeados, D., Tao, Y., Yoshida, S., Asami, T., Chory, J., 2005. A new class of transcription factors mediates brassinosteroid-regulated gene expression in Arabidopsis. Cell 120, 249-259.

Yu, W., Gong, F., Xu, H., Zhou, X., 2024. Molecular mechanism of exogenous ABA to enhance UV-B resistance in rhododendron chrysanthum pall. by modulating flavonoid accumulation. Int. J. Mol. Sci. 25, 5248.

Zeng, D., Lv, J., Li, X., Liu, H., 2025. The Arabidopsis blue-light photoreceptor CRY2 is active in darkness to inhibit root growth. Cell 188, 60-76.e20.

Zhan, J., Di, T., Chen, X., Zheng, T., Sun, W., Yang, M., Zhou, M., Shen, Z., Chen, H., Su, N., 2024. CbMYB108 integrates the regulation of diterpene biosynthesis and trichome development in Conyza blinii against UV-B. Plant Cell Environ. 47, 1300-1318.

Zhang, F., Guo, H., Huang, J., Yang, C., Li, Y., Wang, X., Qu, L., Liu, X., Luo, J., 2020. A UV-B-responsive glycosyltransferase, OsUGT706C2, modulates flavonoid metabolism in rice. Sci. China Life Sci. 63, 1037-1052.

Zhang, F., Huang, J., Guo, H., Yang, C., Li, Y., Shen, S., Zhan, C., Qu, L., Liu, X., Wang, S., et al., 2022a. OsRLCK160 contributes to flavonoid accumulation and UV-B tolerance by regulating OsbZIP48 in rice. Sci. China Life Sci. 65, 1380-1394.

Zhang, F., Yang, C., Guo, H., Li, Y., Shen, S., Zhou, Q., Li, C., Wang, C., Zhai, T., Qu, L., et al., 2024a. Dissecting the genetic basis of UV-B responsive metabolites in rice. Genome Biol. 25, 234.

Zhang, H.-N., Li, W.-C., Wang, H.-C., Shi, S.-Y., Shu, B., Liu, L.-Q., Wei, Y.-Z., Xie, J.-H., 2016. Transcriptome profiling of light-regulated anthocyanin biosynthesis in the pericarp of Litchi. Front. Plant Sci. 07, 963.

Zhang, N., Liu, H., 2025. Switch on and off: Phospho-events in light signaling pathways. J. Integr. Plant Biol. 67, 1756-1770.

Zhang, Q., Lin, L., Fang, F., Cui, B., Zhu, C., Luo, S., Yin, R., 2023. Dissecting the functions of COP1 in the UVR8 pathway with a COP1 variant in Arabidopsis. Plant J. 113, 478-492.

Zhang, Q., Liu, Y., Zhang, C., Xu, D., Medina-Fraga, A. L., Wu, B., Guo, C., Wangzha, M., Yang, G., Zhu, D., et al., 2024b. SlSPA3 regulates the nuclear abundance of SlUVR8 in tomato. Plant J. 120, 2656-2667.

Zhang, Y., Zeng, L., 2020. Crosstalk between ubiquitination and other post-translational protein modifications in plant immunity. Plant Commun 1, 100041.

Zhang, Z., Xu, C., Zhang, S., Shi, C., Cheng, H., Liu, H., Zhong, B., 2022b. Origin and adaptive evolution of UV RESISTANCE LOCUS 8-mediated signaling during plant terrestrialization. Plant Physiol. 188, 332-346.

Zhao, C., Mao, K., You, C.-X., Zhao, X.-Y., Wang, S.-H., Li, Y.-Y., Hao, Y.-J., 2016. Molecular cloning and functional analysis of a UV-B photoreceptor gene, MdUVR8 (UV Resistance Locus 8), from apple. Plant Sci. 247, 115-126.

ZHAO Lijing, LIU Ying, XI Yajun, WANG Xiaofei, GAO Limei, 2022. Cloning and Functional Study of UV-B Photoreceptor Gene MsUVR8 in Medicago sativa L. Acta Bot. Boreal.-Occid. Sin. 42, 29-37 (in Chinese).zh.

Zhao, Y., Min, T., Chen, M., Wang, H., Zhu, C., Jin, R., Allan, A. C., Lin-Wang, K., Xu, C., 2021. The photomorphogenic transcription factor PpHY5 regulates anthocyanin accumulation in response to UVA and UVB irradiation. Front. Plant Sci. 11, 603178.

Zhao, Y., Xing, L., Wang, X., Hou, Y. J., Gao, J., Wang, P., Duan, C. G., Zhu, X., Zhu, J. K., 2014. The ABA receptor PYL8 promotes lateral root growth by enhancing MYB77-dependent transcription of auxin-responsive genes. Sci Signal 7, ra53.

Zhao, Z., Feng, F., Liu, Y., Liu, Y., Wang, F., Ni, Y., Liang, H., Hu, W., Wang, S., Hao, Y., et al., 2025. Blue-light-enhanced interaction between zmcry1s and gl2 modulates epidermal wax composition in zea mays. Nat Commun. 2025 Dec 16. doi: 10.1038/s41467-025-67587-7. Epub ahead of print.

Zinser, C., Seidlitz, H. K., Welzl, G., Sandermann, H., Heller, W., Ernst, D., Rau, W., 2007. Transcriptional profiling of summer wheat, grown under different realistic UV-B irradiation regimes. J. Plant Physiol. 164, 913-922.

Zioutopoulou, A., Patitaki, E., O’Donnell, L., Kaiserli, E., 2022. Low fluence ultraviolet-B promotes Ultraviolet Resistance 8-modulated flowering in Arabidopsis. Front. Plant Sci. 13, 840720.

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