Inter- and intraspecific hybridization shaped the high genetic diversity and low genetic load of Neilingding Island macaques

Shuhao Liu; Ying Shen; Bohua Hou; Dilina Rusitanmu; Jiwei Qi; Ming Li

doi:10.1016/j.jgg.2026.03.020

Turn off MathJax

Article Contents

Article Navigation > Journal of Genetics and Genomics > 2026 > Accepted Manuscript

PDF( 0 KB)

Inter- and intraspecific hybridization shaped the high genetic diversity and low genetic load of Neilingding Island macaques

doi: 10.1016/j.jgg.2026.03.020

1. State Key Laboratory of Animal Biodiversity Conservation and Integrated Pest Management, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China;
2. College of Life Sciences, Hebei University, Baoding, Hebei 071002, China;
3. Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Institute of Zoology, Guangdong Academy of Sciences, Guangzhou, Guangdong 510260, China

Funds:

The work was supported by the National Key Research and Development Projects of the Ministry of Science and Technology of China (2023YFC3304003), GDAS' Project of Science and Technology Development (2025GDAS-BGT-01-001) and State Key Laboratory of Animal Biodiversity Conservation and Integrated Pest Management (SKLA2504).

Received Date: 2025-12-15
Accepted Date: 2026-03-23
Rev Recd Date: 2026-03-19

Available Online: 2026-03-27

Abstract

FullText(HTML)

References(19)

References

Bailey, N., Ruiz, C., Tosi, A., Stevison, L., 2023. Genomic analysis of the rhesus macaque (Macaca mulatta) and the crab-eating macaque (Macaca fascicularis) uncover polygenic signatures of reinforcement speciation. Ecol. Evol. 13, e10571.

Chen, Y., Zhang, S., Zang, W., Ericson, P. G. P., Claramunt, S., Joseph, L., Christidis, L., Zhai, W., Lei, F., Qu, Y., 2025. Balancing selection of climate adaptive loci underlies the success of introduction of Eurasian Tree Sparrows. Sci. Adv. 11, eadw3797.

Chu, Y., Zhan, Q., Yang, Q., Zhang P., Xu H., Xu R., 2019. Population dynamic and viability analysis of Rhesus Macaque (Macaca mulatta) in Neilingding Nature Reserve, Guangdong province. Chin. J. Wildl. 40, 259-266 (in Chinese).

Gu, N., Liu, Y., 2024. Genetic evaluations of island populations of Rhesus Macaque (Macaca mulatta) in China: Implications for conservation management. Zool. Res. Divers. Conserv. 75-78.

Jadejaroen, J., Hamada, Y., Kawamoto, Y., Malaivijitnond, S., 2015. Use of photogrammetry as a means to assess hybrids of rhesus (Macaca mulatta) and long-tailed (M. fascicularis) macaques. Primates 56, 77-88.

Kuderna, L. F. K., Gao, H., Janiak, M. C., Kuhlwilm, M., Orkin, J. D., Bataillon, T., Manu, S., Valenzuela, A., Bergman, J., Rousselle, M., Silva, et al., 2023. A global catalog of whole-genome diversity from 233 primate species. Science, 380, 906-913.

Liu, Z., Tan, X., Orozco-terWengel, P., Zhou, X., Zhang, L., Tian, S., Yan, Z., Xu, H., Ren, B., Zhang, P., et al., 2018. Population genomics of wild Chinese rhesus macaques reveals a dynamic demographic history and local adaptation, with implications for biomedical research. Gigascience 7, giy106.

Mallet, J., 2005. Hybridization as an invasion of the genome. Trends Ecol. Evol. 20, 229-237.

Qi, J., Liu, S., Zhang, L., Zhou, Z., Wang, R., Shen, Y., Teng, Y., Zhang, M., Liu, G., Hu, C., et al., 2025. Drift and isolation drive genomic erosion and island speciation in a lineage of macaques. bioRxiv 2025-09.

Robinson, J. A., Belsare, S., Birnbaum, S., Newman, D. E., Chan, J., Glenn, J. P., Ferguson, B., Cox, L. A., Wall, J. D., 2019. Analysis of 100 high-coverage genomes from a pedigreed captive baboon colony. Genome Res. 29, 848-856.

Tallmon, D.A., Luikart, G., Waples, R.S., 2004. The alluring simplicity and complex reality of genetic rescue. Trends Ecol. Evol. 19, 489-496.

Tan, X., Qi, J., Liu, Z., Fan, P., Liu, G., Zhang, L., Shen, Y., Li, J., Roos, C., Zhou, X., et al., 2023. Phylogenomics reveals high levels of incomplete lineage sorting at the ancestral nodes of the macaque radiation. Mol. Biol. Evol. 40, msad229.

Templeton, A., 1986. Coadaptation and outbreeding depression. Conserv. Biol. 105-116.

Teng, Y., Li, W., Wang, X., Zhang, R., Shen, Y., Wu, R., Liu, J., Zhang, M., Roos, C., Li, J., et al., 2025. Integrating population genomics and environmental data to predict adaptation to climate change in post-bottleneck Tibetan macaques. Sci. Adv. 11, eadw0562.

Wong, C.L., Ni, I.H., 2000. Population dynamics of the feral macaques in the Kowloon Hills of Hong Kong. Am. J. Primatol. 50, 53-66.

Xiao-Jie, L., Ai-Mei, G., Li-Juan, J., Jiang, X., 2015. Pseudogene in cancer: real functions and promising signature. J. Med. Genet. 52, 17-24.

Xiong, Y., Rozzi, R., Zhang, Y., Fan, L., Zhao, J., Li, D., Yao, Y., Xiao, H., Liu, J., Zeng, X., et al., 2024. Convergent evolution toward a slow pace of life predisposes insular endotherms to anthropogenic extinctions. Sci. Adv. 10, eadm8240.

Zhang, B.L., Chen, W., Wang, Z., Pang, W., Luo, M.T., Wang, S., Shao, Y., He, W.Q., Deng, Y., Zhou, L., et al., 2023. Comparative genomics reveals the hybrid origin of a macaque group. Sci. Adv. 9, eadd3580.

Zhang, Z., Zhang, P., Ding, Y., Wang, Z., Ma, Z., Gagnon, E., Jia, Y., Cheng, L., Bao, Z., Liu, Z., et al., 2025. Ancient hybridization underlies tuberization and radiation of the potato lineage. Cell, 188, 5249-5265.

Relative Articles

Supplements(0)

Cited By

Proportional views