a. The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China;
b. State Key Laboratory of Metabolism and Regulation in Complex Organisms, Taikang Center for Life and Medical Sciences, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei 430071, China;
c. Tianjian Laboratory of Advanced Biomedical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China;
d. Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
Funds:
D Program of China and32321004, 32230044, 32371230 and 92354301 from the National Natural Science Foundation of China. This work is also supported by BJ-2024-235 from National High Level Hospital Clinical Research Funding.
Studies in Xun Huang’s laboratory were supported by grants 2024YFA1306101 from National Key R&
Lipids function as central regulators of cellular and systemic physiology through their roles in energy storage, membrane architecture, signaling, and nutrient transport. Maintaining lipid metabolic balance is essential, as its disruption underlies a broad spectrum of metabolic and metabolic-related disorders, including fatty liver disease, obesity, cardiovascular disease, neurodegeneration, and infections. Recent studies have uncovered roles for phospholipids, sphingolipids, lipid-related metabolites, and lipoproteins as metabolic modulators in regulating disease development or mediating inter-organ communication. In this review, we summarize emerging insights into lipid metabolism and metabolite function, with an emphasis on their contribution to the pathogenesis of diseases. We further highlight how these discoveries reshape our understanding of lipid biology and open new avenues for therapeutic intervention.
DownLoad: