tsRNADisease: a manually curated database of tsRNAs associated with human disease

Hui Yang; Shaoying Zhu; Huijun Wei; Wei Huang; Qi Chen; Yungang He; Kun Lv; Zhen Yang

doi:10.1016/j.jgg.2025.08.001

Volume 53 Issue 3

Mar. 2026

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Article Navigation > Journal of Genetics and Genomics > 2026 > 53(3): 537-543

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tsRNADisease: a manually curated database of tsRNAs associated with human disease

doi: 10.1016/j.jgg.2025.08.001

a. Anhui Province Key Laboratory of Non-coding RNA Basic and Clinical Transformation, Tissue Bank, Central Laboratory, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, Anhui 241001, China;
b. Center for Medical Research and Innovation of Pudong Hospital, Fudan University Pudong Medical Center, Intelligent Medicine Institute, Shanghai Medical College, Shanghai Key Laboratory of Intelligent Information Processing, Fudan University, 131 Dongan Road, Shanghai 200032, China;
c. Anhui Province Key Laboratory of Active Biological Macro-molecules Research, Wannan Medical College, Wuhu, Anhui 241001, China;
d. Shanghai Fifth People's Hospital, Fudan University, Shanghai 200032, China

Funds:

The study was supported by the National Natural Science Foundation of China (91959106), the Foundation of the Shanghai Municipal Education Commission (24RGZNC02), Shanghai Key Laboratory of Intelligent Information Processing, Fudan University (IIPL-2025-RD3-02), Key University Science Research Project of Anhui Province (2023AH030108), Climbing Peak Training Program for Innovative Technology team of Yijishan Hospital, Wannan Medical College (PF201904), Peak Training Program for Scientific Research of Yijishan Hospital, Wannan Medical College (GF2019G15), the talent project of the First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College) (YR202422).

Received Date: 2025-04-17
Accepted Date: 2025-08-05
Rev Recd Date: 2025-08-01

Available Online: 2026-03-09

Publish Date: 2026-03-10

Abstract

Abstract

tRNA-derived small RNAs (tsRNAs), as a class of regulatory small noncoding RNA, have been implicated in a wide variety of human diseases. Large amounts of tsRNA–disease associations have been identified in recent years from accumulating studies. However, repositories for cataloging the detailed information on tsRNA–disease associations are scarce. In this study, we provide a tsRNADisease database by integrating experimentally and computationally supported tsRNA–disease associations from manual curation of literatures and other related resources. tsRNADisease contains 5571 manually curated associations between 4759 tsRNAs and 166 diseases with experimental evidence from 346 studies. In addition, it also contains 5013 predicted associations between 1297 tsRNAs and 111 diseases. tsRNADisease provides a user-friendly interface to browse, retrieve, and download data conveniently. This database can improve our understanding of tsRNA deregulation in diseases and serve as a valuable resource for investigating the mechanism of disease-related tsRNAs. tsRNADisease is freely available at http://www.compgenelab.info/tsRNADisease.
- tsRNA,
- Disease,
- Cancer,
- Data integration,
- Database

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References(40)

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