CellReasoner: a reasoning-enhanced large language model for cell type annotation

Guangshuo Cao; Yi Shen; Lingyu Zhao; Jianghong Wu; Haoyu Chao; Ming Chen; Dijun Chen

doi:10.1016/j.jgg.2025.11.012

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CellReasoner: a reasoning-enhanced large language model for cell type annotation

doi: 10.1016/j.jgg.2025.11.012

a. Department of Gastroenterology, Nanjing Drum Tower Hospital, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu 210023, China;
b. Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing, Jiangsu 210023, China;
c. Department of Bioinformatics, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China;
d. College of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, Inner Mongolia 028000, China

基金项目:

The authors acknowledge the High Performance Computing Center of Nanjing University for providing high performance computing (HPC) resources. This work is supported by the Postgraduate Research & Practice Innovation Program of Jiangsu Province and the Yachen Foundation of Nanjing University.

详细信息

通讯作者:
Ming Chen,E-mail:mchen@zju.edu.cn

Dijun Chen,E-mail:dijunchen@nju.edu.cn

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- 被引次数: 0
出版历程
- 收稿日期: 2025-07-16
- 录用日期: 2025-11-20
- 修回日期: 2025-11-20

CellReasoner: a reasoning-enhanced large language model for cell type annotation

Guangshuo Cao^a,b,
Yi Shen^c,
Lingyu Zhao^a,
Jianghong Wu^d,
Haoyu Chao^c,
Ming Chen^{c
, ,},
Dijun Chen^{a,b
, ,}

a. Department of Gastroenterology, Nanjing Drum Tower Hospital, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu 210023, China;
b. Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing, Jiangsu 210023, China;
c. Department of Bioinformatics, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China;
d. College of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, Inner Mongolia 028000, China