E75-induced Toll/NF-κB signaling cooperates with Notch and Hippo pathways to promote tumor malignancy

Xianping Wang; Yifan Guo; Chenglong Wang; Jingjie Mu; Xianjue Ma

doi:10.1016/j.jgg.2025.10.006

E75-induced Toll/NF-κB signaling cooperates with Notch and Hippo pathways to promote tumor malignancy

doi: 10.1016/j.jgg.2025.10.006

1. Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang 310024, China;
2. State Key Laboratory of Gene Expression, School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310024, China;
3. Central Laboratory of Science and Technology Department, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China;
4. Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang 310024, China;
5. State Key Laboratory of Gene Expression, School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310024, China

基金项目:

the Microscopy Core Facility and the High-Performance Computing Center of Westlake University for the facility support and technical assistance. We thank Wenhan Liu for fly stock maintenance. Cartoons were created with BioRender.com. This project was supported by the National Natural Science Foundation of China (32170824 and 32322027 to X.M.), HRHI program of Westlake Laboratory of Life Sciences and Biomedicine (1011103360222B1 to X.M.), “Pioneer” and “Leading Goose” R&

D Program of Zhejiang (2024SSYS0034), and State Key Laboratory of Gene Expression.

We thank Jiong Chen, Oren Schuldiner, Tian Xu, Chenxi Wu, BDSC, VDRC, and DSHB for providing fly stocks and reagents

详细信息

通讯作者:
Xianping Wang,E-mail:wangxianping@westlake.edu.cn

Xianjue Ma,E-mail:maxianjue@westlake.edu.cn

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出版历程
- 收稿日期: 2025-07-06
- 录用日期: 2025-10-26
- 修回日期: 2025-10-23
- 刊出日期: 2026-03-10

E75-induced Toll/NF-κB signaling cooperates with Notch and Hippo pathways to promote tumor malignancy

Xianping Wang^{1,2
, ,},
Yifan Guo^1,2,
Chenglong Wang³,
Jingjie Mu^4,5,
Xianjue Ma^{4,5
, ,}

1. Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang 310024, China;
2. State Key Laboratory of Gene Expression, School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310024, China;
3. Central Laboratory of Science and Technology Department, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China;
4. Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang 310024, China;
5. State Key Laboratory of Gene Expression, School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310024, China

Funds:

D Program of Zhejiang (2024SSYS0034), and State Key Laboratory of Gene Expression.

We thank Jiong Chen, Oren Schuldiner, Tian Xu, Chenxi Wu, BDSC, VDRC, and DSHB for providing fly stocks and reagents

摘要

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参考文献(15)

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Ji, S.M., and Hoffmann, J.A., 2024. Toll-9 prevents the proliferation of injected oncogenic cells in adult flies. J. Genet. Genomics 51, 1331-1333.

Lemaitre, B., Nicolas, E., Michaut, L., Reichhart, J. M., Hoffmann, J. A., 1996. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86, 973-983.

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Reinking, J., Lam, M.M., Pardee, K., Sampson, H.M., Liu, S., Yang, P., Williams, S., White, W., Lajoie, G., Edwards, A., et al., 2005. The Drosophila nuclear receptor E75 contains heme and is gas responsive. Cell 122, 195-207.

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Wang, X.P., Guo, Y.F., Lin, P., Yu, M., Song, S., Xu, W.Y., Kong, D., Wang, Y., Zhang, Y.X., Lu, F., et al., 2024. Nuclear receptor E75/NR1D2 promotes tumor malignant transformation by integrating Hippo and Notch pathways. EMBO J. 43, 6336-6363.

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Zhao, S., Guo, Y., Kuang, X., Li, X., Wu, C., Lin, P., Xie, Q., Zhai, Z., Kong, D., Ma, X., 2025. Hemocytes facilitate interclonal cooperation-induced tumor malignancy by hijacking the innate immune system in Drosophila. EMBO J. 44, 5394-5428.

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E75-induced Toll/NF-κB signaling cooperates with Notch and Hippo pathways to promote tumor malignancy

doi: 10.1016/j.jgg.2025.10.006

通讯作者:
Xianping Wang,E-mail:wangxianping@westlake.edu.cn

Xianjue Ma,E-mail:maxianjue@westlake.edu.cn

计量

E75-induced Toll/NF-κB signaling cooperates with Notch and Hippo pathways to promote tumor malignancy

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留言板

E75-induced Toll/NF-κB signaling cooperates with Notch and Hippo pathways to promote tumor malignancy

doi: 10.1016/j.jgg.2025.10.006

通讯作者: Xianping Wang,E-mail:wangxianping@westlake.edu.cn Xianjue Ma,E-mail:maxianjue@westlake.edu.cn

计量

出版历程

E75-induced Toll/NF-κB signaling cooperates with Notch and Hippo pathways to promote tumor malignancy

计量

出版历程

目录

通讯作者:
Xianping Wang,E-mail:wangxianping@westlake.edu.cn

Xianjue Ma,E-mail:maxianjue@westlake.edu.cn